Association between reward‐related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
Identifieur interne : 000A11 ( Main/Exploration ); précédent : 000A10; suivant : 000A12Association between reward‐related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
Auteurs : Tim Hahn [Allemagne] ; Sebastian Heinzel [Allemagne] ; Thomas Dresler [Allemagne] ; Michael M. Plichta [Allemagne] ; Tobias J. Renner [Allemagne] ; Falko Markulin [Allemagne] ; Peter M. Jakob [Allemagne] ; Klaus-Peter Lesch [Allemagne] ; Andreas J. Fallgatter [Allemagne]Source :
- Human Brain Mapping [ 1065-9471 ] ; 2011-10.
English descriptors
Abstract
The impact of individual differences on human reward processing has been a focus of research in recent years, particularly, as they are associated with a variety of neuropsychiatric diseases including addiction and attention‐deficit/hyperactivity disorder. Studies exploring the neural basis of individual differences in reward sensitivity have consistently implicated the ventral striatum (VS) as a core component of the human reward system. However, the mechanisms of dopaminergic neurotransmission underlying ventral striatal activation as well as trait reward sensitivity remain speculative. We addressed this issue by investigating the triadic interplay between VS reactivity during reward anticipation using functional magnetic resonance imaging, trait reward sensitivity, and dopamine (DA) transporter genotype (40‐bp 3′VNTR of DAT, SLC6A3) affecting synaptic DA neurotransmission. Our results show that DAT variation moderates the association between VS‐reactivity and trait reward sensitivity. Specifically, homozygote carriers of the DAT 10‐repeat allele exhibit a strong positive correlation between reward sensitivity and reward‐related VS activity whereas this relationship is absent in the DAT 9‐repeat allele carriers. We discuss the possibility that this moderation of VS‐trait relation might arise from DAT‐dependent differences in DA availability affecting synaptic plasticity within the VS. Generally, studying the impact of dopaminergic gene variations on the relation between reward‐related brain activity and trait reward sensitivity might facilitate the investigation of complex mechanisms underlying disorders linked to dysregulation of DA neurotransmission. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/hbm.21127
Affiliations:
- Allemagne
- Bade-Wurtemberg, Bavière, District de Basse-Franconie, District de Karlsruhe, District de Tübingen
- Mannheim, Tübingen, Wurtzbourg
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Brain Mapp.</title><idno type="ISSN">1065-9471</idno><idno type="eISSN">1097-0193</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1557">1557</biblScope><biblScope unit="page" to="1565">1565</biblScope></imprint><idno type="ISSN">1065-9471</idno></series><idno type="istex">EC766CD3EABB0A7620F37D24CF16D009166A1E06</idno><idno type="DOI">10.1002/hbm.21127</idno><idno type="ArticleID">HBM21127</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1065-9471</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>dopamine</term><term>fMRI</term><term>genetics</term><term>imaging</term><term>plasticity</term><term>reward</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of individual differences on human reward processing has been a focus of research in recent years, particularly, as they are associated with a variety of neuropsychiatric diseases including addiction and attention‐deficit/hyperactivity disorder. Studies exploring the neural basis of individual differences in reward sensitivity have consistently implicated the ventral striatum (VS) as a core component of the human reward system. However, the mechanisms of dopaminergic neurotransmission underlying ventral striatal activation as well as trait reward sensitivity remain speculative. We addressed this issue by investigating the triadic interplay between VS reactivity during reward anticipation using functional magnetic resonance imaging, trait reward sensitivity, and dopamine (DA) transporter genotype (40‐bp 3′VNTR of DAT, SLC6A3) affecting synaptic DA neurotransmission. Our results show that DAT variation moderates the association between VS‐reactivity and trait reward sensitivity. Specifically, homozygote carriers of the DAT 10‐repeat allele exhibit a strong positive correlation between reward sensitivity and reward‐related VS activity whereas this relationship is absent in the DAT 9‐repeat allele carriers. We discuss the possibility that this moderation of VS‐trait relation might arise from DAT‐dependent differences in DA availability affecting synaptic plasticity within the VS. Generally, studying the impact of dopaminergic gene variations on the relation between reward‐related brain activity and trait reward sensitivity might facilitate the investigation of complex mechanisms underlying disorders linked to dysregulation of DA neurotransmission. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Basse-Franconie</li><li>District de Karlsruhe</li><li>District de Tübingen</li></region><settlement><li>Mannheim</li><li>Tübingen</li><li>Wurtzbourg</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Hahn, Tim" sort="Hahn, Tim" uniqKey="Hahn T" first="Tim" last="Hahn">Tim Hahn</name></region><name sortKey="Dresler, Thomas" sort="Dresler, Thomas" uniqKey="Dresler T" first="Thomas" last="Dresler">Thomas Dresler</name><name sortKey="Fallgatter, Andreas J" sort="Fallgatter, Andreas J" uniqKey="Fallgatter A" first="Andreas J." last="Fallgatter">Andreas J. Fallgatter</name><name sortKey="Fallgatter, Andreas J" sort="Fallgatter, Andreas J" uniqKey="Fallgatter A" first="Andreas J." last="Fallgatter">Andreas J. Fallgatter</name><name sortKey="Hahn, Tim" sort="Hahn, Tim" uniqKey="Hahn T" first="Tim" last="Hahn">Tim Hahn</name><name sortKey="Heinzel, Sebastian" sort="Heinzel, Sebastian" uniqKey="Heinzel S" first="Sebastian" last="Heinzel">Sebastian Heinzel</name><name sortKey="Heinzel, Sebastian" sort="Heinzel, Sebastian" uniqKey="Heinzel S" first="Sebastian" last="Heinzel">Sebastian Heinzel</name><name sortKey="Jakob, Peter M" sort="Jakob, Peter M" uniqKey="Jakob P" first="Peter M." last="Jakob">Peter M. Jakob</name><name sortKey="Jakob, Peter M" sort="Jakob, Peter M" uniqKey="Jakob P" first="Peter M." last="Jakob">Peter M. Jakob</name><name sortKey="Lesch, Klaus Eter" sort="Lesch, Klaus Eter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><name sortKey="Markulin, Falko" sort="Markulin, Falko" uniqKey="Markulin F" first="Falko" last="Markulin">Falko Markulin</name><name sortKey="Plichta, Michael M" sort="Plichta, Michael M" uniqKey="Plichta M" first="Michael M." last="Plichta">Michael M. Plichta</name><name sortKey="Plichta, Michael M" sort="Plichta, Michael M" uniqKey="Plichta M" first="Michael M." last="Plichta">Michael M. Plichta</name><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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